Articles on Beta-amyloid in Jan'09

PLoS ONE Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's DiseaseAmyloid beta Protein. PMID: 19247480

Genetika Studying the pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin PMID: 19239106

CNS Neurosci Ther Comparative neuroprotective properties of stilbene and catechin analogs: action via a plasma membrane receptor site? PMID: 19228181

J Alzheimers Dis. nELAV Proteins Alteration in Alzheimer's Disease Brain: A Novel Putative Target for Amyloid-beta Reverberating on AbetaPP Processing. PMID: 19221430

Protein Pept Lett. Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli. PMID: 19200034

Curr Pharm Des. Multivalent & multifunctional ligands to beta-amyloid. PMID: 19199987

Scand J Clin Lab Invest. Update on amyloid-beta homeostasis markers for sporadic Alzheimer's disease. PMID: 19199126

Transgenic Res. Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw. PMID: 19184503

J Neurochem. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. PMID: 19183260

J Neurosci. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. PMID: 19176820

J Neurosci. A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. PMID: 19176801

FEBS J. A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide. PMID: 19175671

Anal Chem. Screening Assay for Metal-Catalyzed Oxidation Inhibitors Using Liquid Chromatography-Mass Spectrometry with an N-Terminal beta-Amyloid Peptide. PMID: 19173589

Glia. Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling. PMID: 19170180

J Neurosci Res. NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus. PMID: 19170166

Neuroscience. Asymmetric expression patterns of brain transthyretin in normal mice and a transgenic mouse model of Alzheimer's disease. PMID: 19167467

Biochem Biophys Res Commun. IGF-1 promotes beta-amyloid production by a secretase-independent mechanism. PMID: 19167357

Biophys J. Replica exchange simulations of the thermodynamics of Abeta fibril growth PMID: 19167295

Neurobiol Dis. JNK regulates APP cleavage and degradation in a model of Alzheimer's disease. PMID: 19166938

Brain Res. Amyloid beta induces cellular relocalization and production of agrin and glypican-1. PMID: 19166823

Proc Natl Acad Sci U S A. A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis. PMID: 19164538

J Biol Chem. The effects of amyloid precursor protein on post-synaptic composition and activity PMID: 19164281

Bioorg Med Chem. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase. PMID: 19162488

FEBS Lett. Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers. PMID: 19162022

Biochemistry. Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human gamma-Secretase (dagger). PMID: 19159235

PLoS ONE. S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10. PMID: 19159013

Int J Clin Exp Pathol. Cortical Neurons Transgenic for Human Abeta40 or Abeta42 Have Similar Vulnerability to Apoptosis despite Their Different Amyloidogenic Properties. PMID: 19158991

Cell Cycle. Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides. PMID: 19158499

J Alzheimers Dis An intraperitoneally administered pentapeptide protects against Abeta (1-42) induced neuronal excitation in vivo. PMID: 19158435

J Alzheimers Dis. False recognition correlates with amyloid-beta (1-42) but not with total tau in cerebrospinal fluid of patients with dementia and mild cognitive impairment. PMID: 19158431

J Alzheimers Dis. Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta (25-35): involvement of lipid rafts. PMID: 19158430

J Alzheimers Dis. Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration. PMID: 19158422

J Alzheimers Dis. Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization. PMID: 19158421

J Alzheimers Dis. Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease. PMID: 19158417

J Alzheimers Dis Synaptic retrogenesis and amyloid-beta in Alzheimer's disease. PMID: 19158416

Neuroendocrinology. Sulfadiazine Partially Protects the Rat Temporal Cortex from Amyloid Beta Peptide (25-35)-Induced Alterations of the Somatostatinergic System. PMID: 19155612

Brain. Detection of elevated levels of soluble {alpha}-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. PMID: 19155272

Neurosci Lett. Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro. PMID: 19154776

Neurol Sci. The assessment of beta amyloid, tau protein and cystatin C in the cerebrospinal fluid: laboratory markers of neurodegenerative diseases. PMID: 19153649

Neurology. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. PMID: 19153380

Neurology. Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial. PMID: 19153374

Brain. Powerful beneficial effects of macrophage colony-stimulating factor on {beta}-amyloid deposition and cognitive impairment in Alzheimer's disease PMID: 19151372

Vaccine. Reduced oligomeric and vascular amyloid-beta following immunization of TgCRND8 mice with an Alzheimer's DNA vaccine. PMID: 19150380

Recent Pat CNS Drug Discov. Contemporary anticholinesterase pharmaceuticals of natural origin and their synthetic analogues for the treatment of Alzheimer's disease. PMID: 19149713

Recent Pat CNS Drug Discov. Humanin; a defender against Alzheimer's disease? PMID: 19149712

Cell Death Differ. Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. PMID: 19148186

PLoS ONE. Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PMID: 19145255

Neuropsychopharmacology. Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model. PMID: 19145227

FASEB J. Altered Ca2+ dependence of synaptosomal plasma membrane Ca2+-ATPase in human brain affected by Alzheimer's disease. PMID: 19144698

Mol Neurodegener. Insulin-degrading enzyme is exported via an unconventional protein secretion pathway. PMID: 19144176

Dtsch Med Wochenschr. MCI-plus: mild cognitive impairment with rapid progression. Part II: Biomarkers and research methods PMID: 19142839

J Neurochem. Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation. PMID: 19141082

J Neurochem. AZD2184: a radioligand for sensitive detection of -amyloid deposits. PMID: 19141073

Acta Neuropathol. Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. PMID: 19139910

Arch Neurol. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. PMID: 19139300

Neurol Res. Protective effect of ginsenoside Rb1 on beta-amyloid protein(1-42)-induced neurotoxicity in cortical neurons PMID: 19138476

Drug Discov Today. Monitoring the amyloid beta-peptide in vivo - caveat emptor. PMID: 19135168

J Neurosci. Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology. PMID: 19129379

J Mol Neurosci. Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element. PMID: 19127446

Biochem Biophys Res Commun. Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism. PMID: 19126407

Mol Neurodegener. Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. PMID: 19126228

Mol Neurodegener. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. PMID: 19126211

J Neuroinflammation. Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia. PMID: 19123954

J Phys Chem B. Mechanism of hydrogen peroxide production by copper-bound amyloid beta peptide: a theoretical study. PMID: 19123835

Neurochem Res. Upregulation of BACE1 and beta-Amyloid Protein Mediated by Chronic Cerebral Hypoperfusion Contributes to Cognitive Impairment and Pathogenesis of Alzheimer's Disease. PMID: 19123057

Nat Neurosci. Collagen VI protects neurons against Abeta toxicity. PMID: 19122666

Proc Natl Acad Sci U S A. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. PMID: 19122148

J Am Chem Soc. Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide. PMID: 19119811

Alzheimers Dement. Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease. PMID: 19118806

Chembiochem. Identification of physiological and toxic conformations in Abeta42 aggregates. PMID: 19115328

Neurotherapeutics. Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. PMID: 19110209

J Neurochem. A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets. PMID: 19094065

Life Sci. Acetyl-Ile-Gly-Leu protects neurons from Abeta(1-42) induced toxicity in vitro and in V337M human tau-expressing mice. PMID: 19087881

FEBS Lett. Ovine colostrum nanopeptide affects amyloid beta aggregation. PMID: 19084010
Int J Clin Exp Pathol. Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? PMID: 19079646

Neurodegener Dis. Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice. PMID: 19066434

Biochim Biophys Acta. Methionine does not reduce Cu(II)-beta-amyloid!-Rectification of the roles of methionine-35 and reducing agents in metal-centered oxidation chemistry of Cu(II)-beta-amyloid. PMID: 19061952

EMBO Rep. Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. PMID: 19057576

J Mol Biol. A new amyloid-like beta-aggregate with amyloid characteristics, except fibril morphology. PMID: 19041877

J Cell Mol Med. Pharmacotherapeutic targets in Alzheimer's disease. PMID: 19040415

J Biol Chem. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. PMID: 19028695

Neurosci Lett. Indirubin-3'-monoxime inhibits beta-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells. PMID: 19027827

J Pept Sci. FTIR spectroscopic studies on aggregation process of the beta-amyloid 11-28 fragment and its variants. PMID: 19023881

J Biol Chem. Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. PMID: 19017641

Acta Neuropathol. Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease. PMID: 19015863

J Mol Biol. Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. PMID: 19013469

J Neurochem. Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C. PMID: 19012746

Histol Histopathol. The pathology of APP transgenic mice: a model of Alzheimer's disease or simply overexpression of APP? PMID: 19012248

Brain Res. Selective apoptosis induction in the hippocampal mossy fiber pathway by exposure to CT105, the C-terminal fragment of Alzheimer's amyloid precursor protein. PMID: 19007761

Biochem Biophys Res Commun. The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. PMID: 19007750

Acta Neuropathol. Lymphatic drainage of the brain and the pathophysiology of neurological disease. PMID: 19002474

Neurosci Lett. Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease. PMID: 18996438

Brain Res. Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease. PMID: 18996360

Brain Res. Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease. PMID: 18996097

J Biol Chem. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. PMID: 18986979

J Pathol. Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques. PMID: 18973185

J Neural Transm. The neuroprotective effect of dental pulp cells in models of Alzheimer's and Parkinson's disease. PMID: 18972063

Chem Biol Interact. Pregnenolone protects the PC-12 cell line against amyloid beta peptide toxicity but its sulfate ester does not. PMID: 18926803

Neuropsychopharmacology. Target identification for CNS diseases by transcriptional profiling. PMID: 18923405

J Pharmacol Exp Ther. First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates. PMID: 18854490

Phytother Res. Garlic extract exhibits antiamyloidogenic activity on amyloid-beta fibrillogenesis: relevance to Alzheimer's disease. PMID: 18844255

Biosens Bioelectron. Ultra-sensitive immunosensor for beta-amyloid (1-42) using scanning tunneling microscopy-based electrical detection. PMID: 18829296

J Neuroimmunol. Distinct fractional Abeta release patterns in human mononuclear phagocytes. PMID: 18824266

J Neurosci Methods. Characterisation of two antibodies to oligomeric Abeta and their use in ELISAs on human brain tissue homogenates. PMID: 18824027

Neurosci Lett. Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease. PMID: 18786612

J Mol Neurosci. Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells. PMID: 18618086

Scand J Clin Lab Invest. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease. PMID: 18609117

J Mol Neurosci. Parkin attenuates wild-type tau modification in the presence of beta-amyloid and alpha-synuclein. PMID: 18561034

Acta Neurol Scand. Cerebrospinal fluid, serum and plasma protein oxidation in Alzheimer's disease. PMID: 18547271

Brain Pathol. Transthyretin accelerates vascular Abeta deposition in a mouse model of Alzheimer's disease. PMID: 18429966

Neurochem Res. Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice. PMID: 18373196

Mol Psychiatry. The amyloidogenic potential and behavioral correlates of stress. PMID: 17912249

Neurobiol Aging. Menopausal transition: a possible risk factor for brain pathologic events. PMID: 17601638

Neurobiol Aging. Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation. PMID: 17590240

Neurobiol Aging. Knock-out and transgenic mouse models of tauopathies. PMID: 17590238

Neurobiol Aging. Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains. PMID: 17561313